Leucovorin (Folinic Acid) vs. L-Methylfolate (L-MTHF)

This paper highlights the key differences between Leucovorin and L-Methylfolate, two important forms of folate that the body uses in unique ways. Leucovorin has long been used in cancer care and to address folate deficiency, while L-Methylfolate is the fully active form that directly supports mood, detoxification, and those with MTHFR gene variants. Increasingly, these forms of folate are being studied and adapted as part of treatment approaches to support individuals with autism.